Cochrane Handbook for Systematic Reviews of Interventions version 6.3 (updated February 2022). In: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors). Chapter 4: Searching for and selecting studies.
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Published, highly sensitive, validated search filters to identify randomized trials should be considered, such as the Cochrane Highly Sensitive Search Strategies for identifying randomized trials in MEDLINE (but do not apply these randomized trial or human filters in CENTRAL).Ĭite this chapter as: Lefebvre C, Glanville J, Briscoe S, Featherstone R, Littlewood A, Marshall C, Metzendorf M-I, Noel-Storr A, Paynter R, Rader T, Thomas J, Wieland LS.
Medical Subject Headings (MeSH) and Emtree) should be used.
Search strategies should avoid using too many different search concepts but a wide variety of search terms should be combined with OR within each included concept.īoth free-text and subject headings (e.g. Searches should aim for high sensitivity, which may result in relatively low precision. Trials registers should be searched for all Cochrane Reviews and other sources such as regulatory agencies and clinical study reports (CSRs) are increasingly important for identifying study results. The Cochrane Central Register of Controlled Trials (CENTRAL) and MEDLINE, together with Embase (if access to Embase is available to the review team) should be searched for all Cochrane Reviews.Īdditionally, for all Cochrane Reviews, the Specialized Register of the relevant Cochrane Review Groups should be searched, either internally within the Review Group or via CENTRAL. Studies (not reports of studies) are included in Cochrane Reviews but identifying reports of studies is currently the most convenient approach to identifying the majority of studies and obtaining information about them and their results. Review authors should work closely, from the start of the protocol, with an experienced medical/healthcare librarian or information specialist.
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